Health, Longevity & Biohacking
Six Months Cycling Reversed Biological Age by Seven Months, Strongest Exercise Data Yet
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#112 How To Slow Biological Aging With a Multivitamin, Vegetables, & Omega-3 | Dr. Steve Horvath
"They now bicycled 4.5 hours a week. For the health nuts out there, that's not much, but to me, this is daunting. The people who adhered to that trial, they had strong effects on VO2 max. 20%. And then sure enough, suddenly the clocks worked. PC-GrimAge picked up a 7-month reduction."
Horvath highlighted a 2025 Dutch study showing that 6 months of intensive cycling (4.5 hours weekly) reversed biological age by 7 months according to PC-GrimAge, the most robust mortality predictor. This represents the strongest exercise-induced aging reversal on record, far exceeding previous step-count studies. The intervention improved VO2 max by 20%, demonstrating that aging clocks require vigorous exercise, not just daily walking, to show meaningful changes.
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