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Mukherjee says ‘forever chemicals’ and microbiome shifts may drive early colorectal cancer

By Egleze Editorial Desk · Published October 19, 2026 · Peter Attia Drive · 412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more
Mukherjee says ‘forever chemicals’ and microbiome shifts may drive early colorectal cancer
Peter Attia Drive
Peter Attia Drive
412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more

What was said

"we are ingesting more and more forever chemicals. Um, and there is strong evidence from animal models that some of these forever chemicals including the ones that are ingested in food are very pro-inflammatory."

Siddhartha Mukherjee says he does not know what is causing rising colorectal cancer in younger adults, but offers speculative hypotheses. He suggests the colorectal environment may have changed, pointing to greater ingestion of ‘forever chemicals’ and animal-model evidence some are pro-inflammatory, alongside gut microbiome disruption from antibiotics and diet.

Verification status

Attributed speaker claim

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Source and context

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Speaker
Siddhartha Mukherjee · guest
Programme
Peter Attia Drive
Episode
412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more
Clip time
1:21:04
Original source
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From this episode
Peter Attia Drive
Peter Attia Drive

412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more

2h 4m · 7 Egleze moments
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