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Mukherjee says CD19 CAR-T also wipes out healthy B cells

By Egleze Editorial Desk · Published October 19, 2026 · Peter Attia Drive · 412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more
Mukherjee says CD19 CAR-T also wipes out healthy B cells
Peter Attia Drive
Peter Attia Drive
412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more

What was said

"The CAR-T cells that kill B cell leukemias and lymphomas don't just kill B cell leukemias and lymphomas. They kill all B cells."

Siddhartha Mukherjee says CD19 CAR-T responses in some B-cell blood cancers can last because the therapy targets healthy B cells as well as malignant ones. He argues people can survive without B cells, which helps explain why similar CAR-T strategies are harder to apply safely to solid organs.

Verification status

Attributed speaker claim

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Source and context

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Speaker
Siddhartha Mukherjee · guest
Programme
Peter Attia Drive
Episode
412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more
Clip time
1:07:51
Original source
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From this episode
Peter Attia Drive
Peter Attia Drive

412 ‒ The evolving science of cancer: emerging approaches to prevention and early detection, & more

2h 4m · 7 Egleze moments
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