Health, Longevity & Biohacking
Fructose Triggers Ancient Survival Mechanism That Causes Alzheimer's and Metabolic Disease
Feel Better, Live More with Dr Rangan Chatterjee
Brain Doctor: The Foods Quietly Raising Your Alzheimer's Risk (It's NOT Sugar) | David Perlmutter
"Elevation of uric acid does things to pave the way for your survival during times of caloric scarcity. Meaning increased fat production, downregulating mitochondrial function, increasing blood pressure as a hedge against not even finding water... We eat the fructose and fructose is directly metabolized to uric acid. That is a powerful signal to our metabolism to prepare us for winter."
Perlmutter's book 'Drop Acid' reveals that an 8-million-year-old genetic mutation in our primate ancestors created a survival mechanism where fructose consumption triggers uric acid production to prepare for winter scarcity. This mechanism increases fat production, damages mitochondria, and raises blood pressure. Modern year-round fructose availability from high-fructose corn syrup in 80% of American grocery items chronically activates this pathway, driving metabolic dysfunction and neurodegeneration.
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