Health, Longevity & Biohacking
Statin Meta-Analyses Show No Brain Harm and Possible Alzheimer's Protection
Peter Attia Drive
#395 - Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer's disease risk, and the effects of lipid-lowering therapies on brain health | Tom Dayspring, M.D.
"If you look at all the statin trials, the meta-analyses, most of them show statins really have no harm to the brain. But there are a few that do show statins seem to reduce the incidence of Alzheimer's disease cognitive impairment in the brain. None have shown that statins injured the brain."
Contrary to widespread fears about statins harming cognition, Dayspring cited comprehensive meta-analyses of randomized controlled trials showing statins either have neutral effects or actually reduce Alzheimer's and dementia incidence. All statins can cross the blood-brain barrier and may help by reducing excess cholesterol synthesis in neurons, which drives amyloid production.
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Peter Attia Drive