Health, Longevity & Biohacking
Brain Cholesterol System Operates Independently from Blood Cholesterol Levels
Peter Attia Drive
#395 - Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer's disease risk, and the effects of lipid-lowering therapies on brain health | Tom Dayspring, M.D.
"What's going on with cholesterol in the brain, how much cholesterol is stored in the brain, has zero to do with what is floating in the plasma. The ApoB-containing particles, which carry the vast majority of cholesterol, cannot. They're much too big to pass through that blood-brain barrier."
Dr. Tom Dayspring revealed that the brain's cholesterol system is completely separate from peripheral cholesterol circulation. ApoB particles that carry most cholesterol in blood cannot cross the blood-brain barrier. This finding directly challenges widespread misconceptions that lowering LDL cholesterol through medication could harm brain function by depriving it of cholesterol.
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Peter Attia Drive