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Andrew Scull cites NIMH trial reporting 67–82% antipsychotic dropouts

By Egleze Editorial Desk · Published September 17, 2026 · Lex Fridman Podcast · Psychiatry, Insane Asylums, Mental Illness, ECT, Lobotomies, Freud & Jung | Lex Fridman Podcast #502
Andrew Scull cites NIMH trial reporting 67–82% antipsychotic dropouts
Lex Fridman Podcast
Lex Fridman Podcast
Psychiatry, Insane Asylums, Mental Illness, ECT, Lobotomies, Freud & Jung | Lex Fridman Podcast #502

What was said

""Between 67 and 82% of the patients, depending on which drug they were on, dropped out of the trial because either the drug wasn't working or they couldn't stand the side effects.""

Andrew Scull cites an NIMH-funded antipsychotic comparison trial he says was published in the New England Journal of Medicine. He says newer second-generation drugs were no more effective than an older first-generation drug, and that 67% to 82% discontinued due to poor effect or intolerable side effects.

Verification status

Attributed speaker claim

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Source and context

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Speaker
Andrew Scull · guest
Programme
Lex Fridman Podcast
Episode
Psychiatry, Insane Asylums, Mental Illness, ECT, Lobotomies, Freud & Jung | Lex Fridman Podcast #502
Clip time
3:09:42
Original source
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Psychiatry, Insane Asylums, Mental Illness, ECT, Lobotomies, Freud & Jung | Lex Fridman Podcast #502

September 17, 2026 · 3h 36m · 1 Egleze moments
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