← All stories
Health, Longevity & Biohacking

Otvos says unpublished Diabetes Prevention Program analysis found LPIR outperformed insulin

Peter Attia Drive · 402 ‒ NMR blood analysis: how mortality risk and more can be assessed from a single blood sample · August 3, 2026
Otvos says unpublished Diabetes Prevention Program analysis found LPIR outperformed insulin
Peter Attia Drive
Peter Attia Drive
402 ‒ NMR blood analysis: how mortality risk and more can be assessed from a single blood sample
""the study that shows it the best is one that unfortunately hasn't been published yet. It's it got very close to having the manuscript be written. It's in the diabetes prevention program.""
Otvos says analyses using stored samples from the Diabetes Prevention Program (DPP) found the NMR-derived LPIR score predicted diabetes risk better than fasting insulin, and showed lifestyle intervention reduced LPIR more than metformin. He adds later that the work has not been published, attributing delays in part to the primary author’s recent death.
From this episode
Peter Attia Drive
Peter Attia Drive

402 ‒ NMR blood analysis: how mortality risk and more can be assessed from a single blood sample

August 3, 2026 · 2h 27m · 6 Egleze moments
Read episode summary and key points →

More moments from this episode

Health, Longevity & BiohackingOtvos says MVX mortality-risk score is ‘virtually unassociated’ with ageHealth, Longevity & BiohackingNMR ‘glyc’ inflammation marker described as more stable than CRPHealth, Longevity & BiohackingOtvos says ‘fluffy’ LDL does not offset risk when LDL particle count is highAI & TechOtvos says NMR plus machine learning can output ApoB and lipid panel cheaply
More stories More from Peter Attia Drive