Health, Longevity & Biohacking
Gary Brecka warns GLP-1 trials show substantial lean-mass loss
The Ultimate Human
The GLP-1 Side Effect Nobody Warns You About | TUH #291
"A 2024 review published in Diabetes, Obesity and Metabolism examined lean body mass changes across GLP-1 clinical trials and found that in some studies reductions in lean mass accounted for 40 to 60% of the total weight lost. Let me say that again. 60% of the weight loss was from muscle dense tissue."
Gary Brecka says a 2024 review in the journal Diabetes, Obesity and Metabolism found that, in some GLP-1 clinical trials, reductions in lean mass made up 40–60% of total weight lost. He argues this can reduce resting energy expenditure and functional strength, and says patients using GLP-1 medicines should pair them with resistance training and adequate protein intake to mitigate muscle loss.
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