Jessie Inchauspé, who writes about blood sugar and diet, explains what glucose is and why she believes frequent “spikes” and crashes can contribute to fatigue, cravings and long-term metabolic illness. She describes three mechanisms she associates with sharp glucose rises: impaired energy production (via mitochondria), accelerated “glycation” linked to ageing, and inflammation, before discussing insulin’s role in storing excess glucose and its relationship to type 2 diabetes risk.
Much of the episode focuses on practical dietary tactics. Inchauspé argues that a sweet, carb-heavy breakfast can set up a day of cravings and low energy, and recommends switching to a savoury, protein-centred breakfast. She also cites research suggesting that eating foods in a particular sequence—vegetables first, then proteins and fats, with starchy or sweet items last—can sharply reduce the size of a glucose spike.
In a more personal section, she recounts a decade of anxiety, depression and depersonalisation after a teenage accident, saying a pilot glucose-monitor experiment helped her notice that her mental health was worse on days with larger glucose swings. She also advises snackers to avoid eating carbohydrates “naked”, pairing them with protein, fat or fibre. The conversation ends with a caution about over-tracking health metrics and her suggested policy idea of banning processed breakfast foods.
Jessie Inchauspé tells Jay Shetty her mental health declined after a teenage back injury and years of anxiety, depression and depersonalisation followed. She says a pilot trial using a continuous glucose monitor showed worse symptoms on days with big glucose spikes and drops, and improvement when levels were steadier.
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