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Health, Longevity & Biohacking

Eric Andre Admits to SSRIs After Years Avoiding Medication for Comedy

By Egleze Editorial Desk · Published July 8, 2026 · Conan O'Brien Needs A Friend · Eric Andre Returns Again
Eric Andre Admits to SSRIs After Years Avoiding Medication for Comedy
Conan O'Brien Needs A Friend
Conan O'Brien Needs A Friend
Eric Andre Returns Again

What was said

"I got on them pretty late for a guy with my affliction. I know in my case it was just Nope, you don't take anything to make life easier. If anything, you do things to make life harder. I was annoying. It doesn't change who you are or anything. I thought it would. That's why I didn't do it. I was like, I won't be comedic."

Andre opened up about starting SSRIs late in life after years of resistance, believing medication would diminish his comedic ability. He discussed anxiety, obsessive compulsive thought loops, and depression, crediting Andy Richter for encouraging him to seek help. Both Andre and O'Brien shared fears that antidepressants would fundamentally alter their personalities and creative output, a common concern among comedians.

Verification status

Attributed speaker claim

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Source and context

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Programme
Conan O'Brien Needs A Friend
Episode
Eric Andre Returns Again
Clip time
45:34
Original source
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From this episode
Conan O'Brien Needs A Friend
Conan O'Brien Needs A Friend

Eric Andre Returns Again

June 29, 2026 · 4 Egleze moments
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