← All stories
Health, Longevity & Biohacking

Eric Andre Admits to SSRIs After Years Avoiding Medication for Comedy

Conan O'Brien Needs A Friend · Eric Andre Returns Again · June 29, 2026
Eric Andre Admits to SSRIs After Years Avoiding Medication for Comedy
Conan O'Brien Needs A Friend
Conan O'Brien Needs A Friend
Eric Andre Returns Again
"I got on them pretty late for a guy with my affliction. I know in my case it was just Nope, you don't take anything to make life easier. If anything, you do things to make life harder. I was annoying. It doesn't change who you are or anything. I thought it would. That's why I didn't do it. I was like, I won't be comedic."
Andre opened up about starting SSRIs late in life after years of resistance, believing medication would diminish his comedic ability. He discussed anxiety, obsessive compulsive thought loops, and depression, crediting Andy Richter for encouraging him to seek help. Both Andre and O'Brien shared fears that antidepressants would fundamentally alter their personalities and creative output, a common concern among comedians.
From this episode
Conan O'Brien Needs A Friend
Conan O'Brien Needs A Friend

Eric Andre Returns Again

August 3, 2026 · 4 Egleze moments
Read episode summary and key points →

More moments from this episode

ComedyAndre Confesses to Photoshopping Fake Injuries to Torment Knicks Fan FriendsEntertainmentAndre Details John Cena Stunt Gone Wrong Causing Concussion on SetCrime & JusticeEric Andre Reveals William S. Burroughs Used Apple Defense After Killing Wife
More stories More from Conan O'Brien Needs A Friend