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Most Magnesium Supplements Cannot Cross Blood-Brain Barrier to Affect Sleep

By Egleze Editorial Desk · Published June 27, 2026 · Diary of a CEO · Most Replayed Moment: Sleep Expert On The Truth About Melatonin And Magnesium
Most Magnesium Supplements Cannot Cross Blood-Brain Barrier to Affect Sleep
Diary of a CEO
Diary of a CEO
Most Replayed Moment: Sleep Expert On The Truth About Melatonin And Magnesium

What was said

"Most forms of magnesium, magnesium oxide or magnesium citrate, Most of these forms of magnesium don't cross the blood-brain barrier, and sleep is produced by your brain. So how can something that doesn't get into your brain affect a brain process, number one?"

Walker challenged the popular trend of magnesium supplementation for sleep, revealing that the most common forms cannot cross the blood-brain barrier. He explained that original magnesium-sleep research only showed benefits in magnesium-deficient individuals returning to normal levels, not in people with already-normal magnesium who are creating what he called expensive urine. Only magnesium L-threonate shows some evidence of brain penetration.

Verification status

Attributed speaker claim

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Source and context

Egleze verified who said this and where. The underlying claim has not been independently established by Egleze.

Programme
Diary of a CEO
Episode
Most Replayed Moment: Sleep Expert On The Truth About Melatonin And Magnesium
Clip time
1:05:47
Original source
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From this episode
Diary of a CEO
Diary of a CEO

Most Replayed Moment: Sleep Expert On The Truth About Melatonin And Magnesium

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