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Health, Longevity & Biohacking

Major Vitamin D Clinical Trials Failed to Show Any Health Benefits

Joe Rogan Experience · #2516 - Rowan Jacobsen · June 18, 2026
Major Vitamin D Clinical Trials Failed to Show Any Health Benefits
Joe Rogan Experience
Joe Rogan Experience
#2516 - Rowan Jacobsen
"Everyone thought, like back in the '80s, '90s, everyone started noticing, scientists started noticing that people who naturally had people with lower amounts of vitamin D in their blood had higher rates of all like the classic chronic diseases. So they started recommending vitamin D pills. So then they did all these clinical trials to prove that it would help. Huge, huge clinical trials, tens of thousands of people, follow-ups that went for many years. None of them showed a benefit."
Despite observational data linking natural vitamin D levels to lower disease rates, massive clinical trials of vitamin D supplementation showed zero benefit for any condition. The New England Journal of Medicine published an editorial in 2022 recommending doctors stop prescribing it. Natural vitamin D from sun exposure, however, correlates strongly with reduced mortality.

About this episode

Joe Rogan sits down with science journalist Rowan Jacobsen, author of In Defense of Sunlight, for a provocative two-hour deep dive into the suppressed science of sun exposure and the institutional resistance he's faced for reporting it. Jacobsen reveals he has been formally denounced multiple times by the American Academy of Dermatology for publishing data showing cardiovascular, mood, and longevity benefits from moderate sunlight, despite zero-sun recommendations being based almost entirely on skin cancer risk for the fairest-skinned populations. The conversation exposes how American sunscreen formulations have remained 30 years behind Europe and Asia due to FDA drug classification and manufacturers refusing to fund safety studies, while old chemical sunscreens blocked burning UVB rays but let cancer-causing UVA through. Most strikingly, Jacobsen details how massive clinical trials of vitamin D supplementation failed completely to replicate the health benefits seen in people with naturally high vitamin D from sun exposure, leading the New England Journal of Medicine to recommend doctors stop prescribing it in 2022. The episode explores how dermatologists refuse interdisciplinary conversation despite evidence that outdoor workers have lower melanoma rates than office workers, how sunlight directly triggers opiate release in the brain and improves cognition, and why one-size-fits-all sun avoidance recommendations ignore skin color despite dark-skinned individuals having negligible sun cancer risk and massive cardiovascular benefit from exposure. Rogan and Jacobsen also discuss melanotan peptides that cause extreme tanning and erections, the corruption of the American food supply compared to Mediterranean diets, why red light therapy reversed Rogan's macular degeneration, and the bizarre case of truck driver face. The conversation is a case study in how scientific institutions calcify around outdated paradigms and punish researchers who present contradictory data, even when the evidence is overwhelming.

Key takeaways

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