Health, Longevity & Biohacking
Rapid GLP-1 Withdrawal Causes Weight Regain Primarily as Fat Not Muscle
ZOE Science & Nutrition
The 4 rules to protect your muscle, bones and brain health when using Ozempic and other weight loss injections | Dr Federica Amati
"If you then come off the drugs, you will regain the weight lost mostly as fat mass. It's much easier for our bodies to store fat mass. There's a term for this, which is called sarcopenic obesity. You have increased fat mass and much reduced lean mass."
Dr. Amati warned that stopping GLP-1 medications abruptly without tapering leads to a dangerous rebound effect where users regain weight predominantly as fat while losing muscle mass, creating worse metabolic health than before treatment. This condition, sarcopenic obesity, increases risks for type 2 diabetes, fatty liver disease, and hypertension beyond initial baseline levels.
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ZOE Science & Nutrition