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Health, Longevity & Biohacking

Morphine Didn't Work on SEAL Due to Genetic Blood Abnormality

Huberman Lab · The Mental Frame & Specific Daily Actions to Succeed | Andy Stumpf · June 15, 2026
Morphine Didn't Work on SEAL Due to Genetic Blood Abnormality
Huberman Lab
Huberman Lab
The Mental Frame & Specific Daily Actions to Succeed | Andy Stumpf
"I kept asking for more morphine, and the guy pulled out a chart and said, this is what you weigh, this is your dosage, you are now at the threshold. If we give you more, your heart's gonna stop. My sister and I have a genetic blood abnormality where I don't process opiates the same way as people do."
Stumpf revealed a genetic condition he shares with his sister that prevents proper processing of opioid medications, making morphine ineffective for pain management even at dangerous doses. This discovery came during emergency treatment in Baghdad after being shot, and later during an intestinal blockage emergency that became the most painful experience of his life, worse than gunshot wounds or SEAL training.

About this episode

Andrew Huberman sits down with retired Navy SEAL Andy Stumpf for a far-reaching conversation that moves beyond typical SEAL Team narratives into profound territory on mental health, discipline, and suicide. Stumpf, who also set two world records in wingsuit flying, discusses his book 'Drown Proof' and reveals tools for managing everyday life that both he and Huberman now use regularly. The centerpiece discussion examines a simple but powerful exercise separating concerns from influence that has transformed how both men approach daily stress. Stumpf drops a stunning statistic: Green Beret community losses to suicide now exceed combat deaths since 2001, with SEAL teams likely close behind. He shares intimate details about his friend Dave's suicide, describing how the decorated operator struggled with alcohol and a devastating gap between self-perception and how others viewed him. Stumpf reveals his own genetic inability to process opioid pain medication, discovered after being shot in Baghdad. The conversation turns philosophical as Huberman proposes that evil forces exploit psychological vulnerabilities through shame, suggesting solutions to suicidality may require perspectives beyond pure science. Stumpf candidly discusses his contentious divorce as harder than anything in SEAL training, and how wingsuit BASE jumping provided crucial mental resets for months afterward. Throughout, both men emphasize choosing slightly harder paths in small daily decisions as foundational to long-term success and well-being.

Key takeaways

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