Health, Longevity & Biohacking
Genetic Medicine Platform Enables Tumors to Signal Immune System Creating Abscopal Cancer Destruction
Tim Ferriss Show
#868: Tim’s Founder Kitchen — From Brainstorm to The President’s Office in Two Months (Featuring Jake Becraft, Strand Therapeutics)
"Instead of just blocking the tumor's ability to hide, you actually have a tumor that's sort of screaming like, I am a foreign object. Please come and eat me. What we're doing is we're sort of resetting that system. We're having the tumors resend the signal out. The immune system comes into the tumor and it kills it, but then it gets activated by that killing process and it learns what the tumors look like and it can better identify the other tumors that have been hiding throughout the body."
Becraft explained Strand's breakthrough mechanism that delivers genetic instructions into cancer cells, causing tumors to emit distress signals that activate the immune system. Unlike traditional checkpoint inhibitors that merely unmask cancer, this approach reprograms cancer cells to actively signal for immune destruction. The therapy creates a cascade effect where the immune system learns to recognize and hunt metastatic tumors throughout the body after treating just one lesion.
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Tim Ferriss Show