On Purpose with Jay Shetty
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How to ACTUALLY Lose Belly Fat (Based on Science) | Dr. Mindy Pelz

On Purpose with Jay Shetty · 26 August 2026 · 45m · 4 Egleze moments
How to ACTUALLY Lose Belly Fat (Based on Science) | Dr. Mindy Pelz ▶

What happened in this episode?

Jay Shetty interviews fasting and nutrition author Dr Mindy Pelz on strategies she says are supported by science for reducing “belly fat”, improving metabolic health, and building sustainable eating habits. Pelz argues that repeating the same fasting pattern daily can backfire because the body adapts, and she recommends tailoring fasting and eating windows to lifestyle and goals, including earlier cut-offs for evening eating to reduce insulin resistance.

A major theme is blood-sugar regulation: Pelz contends that meal composition and glucose “recovery” after eating matter more than calorie counting, describing a patient example using a continuous glucose monitor to reduce glucose spikes by adding fat and fibre. She cites time-restricted eating research she attributes to Satchin Panda, claiming an eight-hour eating window can reduce metabolic harm markers even with a processed diet.

Pelz also makes broader environmental-health claims, alleging modern exposures to chemicals in skincare and food (“obesogens”) contribute to fat gain and can affect stem-cell development; these statements are presented without detailed sourcing in the episode. She describes a personal trial of higher protein intake (one gram per pound of body weight) that she says increased fat gain for her, and advises listeners to individualise targets. The conversation also turns to women’s health and body image, with Pelz linking restrictive dieting to loss of menstrual cycles among younger women and arguing cultural ideals can push people into hormonal imbalance.

The episode closes on accessibility, with Pelz framing fasting as a low-cost tool for people without access to wearables or expensive health foods.

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Programme
On Purpose with Jay Shetty
Published
26 August 2026
Duration
45m
Original episode
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4 moments from this episode

Source-linked · editorially selected
01
Health, Longevity & Biohacking

Dr Mindy Pelz claims everyday chemicals ‘reprogramme’ stem cells to create fat

at 10:57 · Attributed speaker claim
We live in the most toxic time in human history. Women are putting over 200 toxic carcinogenic [snorts] chemicals on their skin every single day. The brilliant body is like, I don't know what to do with all this, so I'm going to put it around your belly and your chest.

Dr Mindy Pelz says modern chemical exposure contributes to weight gain, arguing that the body stores toxins as fat, particularly around the abdomen and chest. She alleges women are exposed to “over 200” carcinogenic chemicals daily via skin products and recommends reducing ‘toxic load’ through product and food choices and “different detoxes”.

02
Health, Longevity & Biohacking

Pelz says obesogens in food ‘reprogramme’ stem cells, citing UK impacts

at 12:19 · Attributed speaker claim
What they do is they literally those chemicals go into stem cells and they reprogram those stem cells to actually make fat cells. And one of the places we're seeing this is in the UK right now because kids have low have lots of stem cells and as we get older we have less.

Pelz argues that ‘obesogens’—including plastics such as BPA, pesticides, and additives—can drive fat gain by altering stem-cell development. She claims this is visible “in the UK right now”, alleging children’s stem cells are making fat rather than bone, contributing to kids becoming “shorter than ever before” and “bigger than ever before”.

03
Health, Longevity & Biohacking

Dr Mindy Pelz says 16:8 eating windows can ‘protect’ metabolism

at 18:41 · Attributed speaker claim
what he found is that if you ate all your food in an 8-hour eating window leaving 16 hours for rest and recovery that you basically became metabolically immune from the harsh metabolic consequences of a processed diet.

Dr Mindy Pelz cites research she attributes to Satchin Panda and says time-restricted eating — consuming all food within an eight-hour window — can reduce metabolic harms even when diet quality is poor. She claims it can prevent rises in insulin, HbA1c and inflammatory markers such as CRP, and argues the fasting window matters more than calorie counting.

04
Society

Dr Mindy Pelz says dieting for social media ideals can stop periods

at 37:35 · Attributed speaker claim
how many 20 year olds and 30-year-olds don't have a menstrual cycle. And they don't have a menstrual cycle because they've been manipulating their diet. Their diet's too low calorie.

Dr Mindy Pelz says she has seen many women in their 20s and 30s lose their menstrual cycle after restricting calories to match culturally promoted body types. She argues this kind of weight loss can disrupt hormones and that some fat gain may be normal under oestrogen-driven physiology.